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. 2022 Jul 26;99(4):e323–e333. doi: 10.1212/WNL.0000000000200573

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Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Postmortem non-AD pathologies including (A) α-synuclein Lewy bodies and (B) TDP-43. All plots show antemortem MRI-based typicality on the horizontal scale, proxied by the index = ; all plots show antemortem MRI-based severity on the vertical scale, proxied by the Global Brain Atrophy Index = , whereby higher values correspond to lower severity. A + E = TDP-43 immunoreactive inclusions are present in the amygdala and entorhinal/inferior temporal cortex; A + H + E + N = TDP-43 immunoreactive inclusions are present in the amygdala, hippocampus, entorhinal/inferior temporal cortex, and neocortex; A + H + E = TDP-43 immunoreactive inclusions are present in the amygdala, hippocampus, and entorhinal/inferior temporal cortex; AD = Alzheimer disease; TDP-43 = TAR DNA-binding protein 43.

Inline graphic — Postmortem non-AD pathologies including (A) α-synuclein Lewy bodies and (B) TDP-43. All plots show antemortem MRI-based typicality on the horizontal scale, proxied by the index = ; all plots show antemortem MRI-based severity on the vertical scale, proxied by the Global Brain Atrophy Index = , whereby higher values correspond to lower severity. A + E = TDP-43 immunoreactive inclusions are present in the amygdala and entorhinal/inferior temporal cortex; A + H + E + N = TDP-43 immunoreactive inclusions are present in the amygdala, hippocampus, entorhinal/inferior temporal cortex, and neocortex; A + H + E = TDP-43 immunoreactive inclusions are present in the amygdala, hippocampus, and entorhinal/inferior temporal cortex; AD = Alzheimer disease; TDP-43 = TAR DNA-binding protein 43.