Fig. 6.

The expressions of OPA1 in human valve interstitial cells was increased by fructose at high concentration. Representative gels and densitometric analyses of (A) full length optic atrophy 1 (OPA1) (B)cleaved OPA1 (C) mitofusin 1 (MFN1) and (D) MFN2 detected at 24 h incubated with 0, 2, or 20 mM fructose. Values are mean ± SEM, n = 4–6 in each experimental group. The sample size of each group was noted on the bar. ∗p < 0.05, ∗∗p < 0.01 versus 0 mM fructose group using the nonparametric, Kruskal–Wallis test followed by the Dunn post hoc method.