Fig. 7.

The expressions of cleaved PINK1 in human valve interstitial cells was increased by fructose at high concentration. Representative gels and densitometric analyses of (A) full length phosphatase and tensin homolog (PTEN)-induced putative kinase protein 1 (PINK1) (B) cleaved PINK1 (C) full length Parkin, and (D) cleaved Parkin detected at 24 h incubated with 0, 2, or 20 mM fructose. Values are mean ± SEM, n = 4–6 in each experimental group. The sample size of each group was noted on the bar. ∗∗p < 0.01 versus 0 mM fructose group using the nonparametric, Kruskal–Wallis test followed by the Dunn post hoc method.