FIGURE 2.

The schematic illustrates the generation of genetic progression score (GPS) based on the number of accumulated aberrations and time of occurrence of the aberrations from a computed temporal oncogenic tree or trajectory pathway (i.e., late event vs. early event) [27]. A late event obtains a higher weighted value than an earlier event, for example, 1p36 loss is assigned a higher value than −13; thus, higher number of accumulated aberrations and late events receive a higher score