TABLE 5:
Screening Performance, Stratified by Reader and Protocol
| Protocol | Sensitivity | Specificity | PPV | NPV | Accuracy | AUC |
|---|---|---|---|---|---|---|
|
| ||||||
| Reader 1 | ||||||
| Standard | 90 (18/20) [68–99] | 81 (331/407) [77–85] | 19 (18/94) [12–29] | 99 (331/333) [99–100] | 82 (349/427) [78–85] | 0.94 [0.91–0.97] |
| Abbreviated | 90 (18/20) [68–90] | 78 (319/407) [74–82] | 17 (18/106) [10–26] | 99 (319/321) [98–100] | 79 (337/427) [75–83] | 0.89 [0.81–0.95] |
| Abbreviated plusT2-weighted | 95 (19/20) [75–100] | 82 (332/407) [77–85] | 20 (19/94) [13–30] | 100 (332/333) [98–100] | 82 (351/427) [78–86] | 0.91 [0.83–0.98] |
| Reader 2 | ||||||
| Standard | 95 (19/20) [75–100] | 79 (320/407) [75–83] | 18 (19/106) [11–27] | 100 (320/321) [98–100] | 79 (339/427) [75.5–83.4] | 0.93 [0.89–0.96] |
| Abbreviated | 100 (20/20) [80–100] | 75 (306/407) [71–79] | 20 (20/101) [10–24] | 100 (306/306) [80–100] | 76 (326/427) [72–80] | 0.92 [0.89–0.94] |
| Abbreviated plusT2-weighted | 95 (19/20) [75–100] | 81 (330/407) [77–85] | 20 (19/96) [12–29] | 100 (330/331) [98–100] | 82 (349/427) [78–85] | 0.92 [0.87–0.96] |
| Reader 3 | ||||||
| Standard | 95 (19/20) [75–100] | 73 (299/407) [69–78] | 15 (19/127) [9–22] | 100 (299/300) [98–100] | 74 (318/427) [70–79] | 0.85 [0.74–0.95] |
| Abbreviated | 90 (18/20) [68–99] | 50 (204/407) [45–55] | 8 (18/221) [5–12] | 99 (204/206) [97–100] | 52 (222/427) [47–57] | 0.80 [0.72–0.87] |
| Abbreviated plusT2-weighted | 80 (16/20) [56–94] | 81 (328/407) [76–84] | 17 (16/95) [10–26] | 99 (328/332) [97–100] | 80 (344/427) [76–84] | 0.90 [0.85–0.94] |
| Reader 4 | ||||||
| Standard | 95 (19/20) [75–100] | 86 (352/407) [83–90] | 26 (19/74) [16–37] | 100 (352/353) [98–100] | 87 (371/427) [83–90] | 0.95 [0.92–0.97] |
| Abbreviated | 90 (18/20) [68–99] | 84 (340/407) [80–87] | 21 (18/85) [13–31] | 99 (340/342) [98–100] | 84 (358/427) [80–87] | 0.89 [0.82–0.97] |
| Abbreviated plusT2-weighted | 90 (18/20) [68–99] | 88 (357/407) [84–91] | 27 (18/67) [16–38] | 99 (357/359) [98–100] | 88 (375/427) [84–91] | 0.90 [0.81–0.98] |
| Pooled | ||||||
| Standard | 94 (75/80) [81–99] | 80 (1303/1628) [76–83] | 19 (75/399) [12–27] | 100 (1303/1308) [99–100] | 81 (1378/1708) [79–82] | 0.92 [0.89–0.94] |
| Abbreviated | 92 (74/80) [80–98] | 72 (1167/1628) [68–75] | 14 (74/534) [9–21] | 99 (1167/1173) [98–100] | 73 (1241/1708) [71–75] | 0.88 [0.85–0.91] |
| Abbreviated plusT2-weighted | 90 (72/80) [76–97] | 83 (1346/1628) [79–86] | 20 (72/353) [13–30] | 99 (1346/1354) [98–100] | 83 (1418/1708) [81–85] | 0.90 [0.87–0.94] |
Note—Except for AUC, values are percentage with number of examinations in parentheses. Values in brackets are 95% CI.