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. 2022 Jun 24;3(4):161–170. doi: 10.1016/j.cvdhj.2022.06.001

Table 3.

Genetic loci associated with predicted heart rate recovery

Chr SNP Effect allele / Referent allele EAF Gene Location Beta s.e. P Selected prior trait associations
2 rs142556838 C/T 0.91 CCDC141 Intron 0.306 0.055 2.30E-08 Heart rate27
6 6:122113614 CT/C 0.90 GJA1 0.378 0.052 3.30E-13 Cardiac conduction29
7 rs221789 C/T 0.15 GNB2 5' utr -0.246 0.043 4.80E-09 Familial sinus node and atrioventricular conduction dysfunction30,33
7 rs1997571 A/G 0.41 CAV1 Intron -0.197 0.032 5.60E-10 Insulin resistance, metabolic syndrome32
12 rs4963772 A/G 0.85 BCAT1 Intergenic -0.244 0.044 2.20E-08 Heart rate variability28
14 rs422068 T/C 0.64 MYH6 Intron 0.205 0.033 1.70E-10 Familial cardiomyopathy, rare variant also associated with sick sinus syndrome31,42
20 rs6127466 G/A 0.53 KIAA1755 Intron -0.197 0.031 2.50E-10 Heart rate27
21 rs2846867 C/T 0.98 C21orf37 Intergenic 0.181 0.031 7.40E-09

BCAT1 = branched chain amino acid transaminase 1; CAV1 = caveolin-1; CCDC141 = coiled-coil domain containing 141; Chr = chromosome; EAF = estimated allele frequency; GJA1 = gap junction protein alpha 1; GNB2 = G protein subunit beta 2; MYH6 = myosin heavy chain 6; s.e. = standard error; SNP = single nucleotide polymorphism.