. Author manuscript; available in PMC: 2022 Aug 29.

Published in final edited form as: Cytokine Growth Factor Rev. 2019 Oct 24;49:1–9. doi: 10.1016/j.cytogfr.2019.10.002

Table 2.

Current list of ongoing pre-clinical trials using immune checkpoint inhibitors.

Author	Study Title	Methods	Results
Jure-Kunkel et al. [55]	“Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models”	Subcutaneous CRC mouse model with CTLA4	Reduced tumor growth in both treatment groups
Zhao et al. [56]	“Tumor location impacts immune response in mouse models of colon cancer”	Orthotopic CRC and subcutaneous allograft	Orthotopic models were more sensitive to checkpoint inhibition