Extended Data Fig. 4 |. Dual-CAR T cell product transiently delays CD4+ T cell loss despite persistent HIV_JRCSF infection.

BLT mice received Dual-CAR T cell product (TCP) (n = 6) 48 h after HIV_JRCSF challenge, while control mice were untreated (Untx) (n = 5). a, Concentration of peripheral total memory CD4⁺ T cells (CAR⁻). b, Concentration of peripheral central memory (CD45RA−CD27⁺CCR7⁺; left panel), transitional memory (CD45RA⁻CD27⁺CCR7⁻; middle panel), and effector memory (CD45RA⁻CD27⁻CCR7⁻; right panel) CD4⁺ T cells (CAR⁻). c, Frequency of memory CD4⁺ T cell (CAR⁻) subsets in tissues 8 weeks post-infection. a, b, Significance was calculated using a two-sided Wilcoxon rank-sum test. Symbols and bars indicate mean, and error bars show ± SEM. Sample sizes indicate biologically independent animals.