Extended Data Fig. 5 |. Dual-CAR T cell product prevents CD4+ T cell loss despite persistent HIV_MJ4 infection.

BLT mice were infused with Dual-CAR T cell product (TCP) (n = 6) 48 h post-HIV_MJ4 challenge, while control mice were untreated (Untx) (n = 6). a, Concentration of peripheral total memory CD4⁺ T cells (CAR⁻). b, Concentration of peripheral central memory (CD45RA⁻CD27⁺CCR7⁺; right panel), transitional memory (CD45RA⁻CD27⁺CCR7⁻; middle panel), and effector memory (CD45RA⁻CD27⁻CCR7⁻; left panel) CD4⁺ T cells (CAR⁻). c, Frequency of memory CD4⁺ T cell (CAR⁻) subsets in tissues 8 weeks post-infection. a, b, Significance was calculated using a two-sided Wilcoxon rank-sum test. Symbols and bars indicate mean, while error bars show ± SEM. Sample sizes indicate biologically independent animals.