Table 4.
Univariate and multivariate analysis of independent predictors for treatment success
| Independent factors | Treatment success | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| OR (95%CI) | p value | OR (95%CI) | p value | |||
| Age | ||||||
| < 35 years | 72 (85.7) | – | – | – | – | |
| 35–60 years | 73 (73.0) | 0.45 (0.2–1.0) | 0.04 | 2.7 (0.6–11.4) | 0.2 | |
| ≥ 60 years | 14 (77.8) | 0.6 (0.16–2.1) | 0.6 | 1.0 (0.3–3.6) | 1.0 | |
| Type of drug resistance | – | – | ||||
| RR | 5 (62.5) | – | – | – | – | |
| MDR | 116 (76.3) | 0.83 (0.2–3.8) | 0.8 | – | – | |
| XDR | 36 (58.1) | 2.7 (0.6–11.9) | 0.2 | – | – | |
| Gender (male/female) | 114 (77.0)/42 (79.2) | 0.9 (0.4–1.9) | 0.8 | – | – | |
| History of TB treatment (new/previously treated) | 16 (84.2)/141 (77.0) | 1.6 (0.4–5.7) | 0.5 | – | – | |
| Cavitary disease at baseline (yes/no) | 114 (81.4)/39 (72.2) | 0.6 (0.3–1.2) | 0.2 | – | – | |
| Concomitant diabetes (yes/no) | 21 (72.4)/136 (78.6) | 1.4 (0.6–3.4) | 0.5 | – | – | |
| Treatment regimen (bedaquiline/non-bedaquiline) | 94 (92.2)/63 (63.0) | 6.9 (3.0–15.8) | < 0.001* | 7.4 (2.9–18.5) | < 0.001* | |
| Regimen containing (BDQ+ Cfz)/Cfz | 87 (94.6)/29(58.0) | 12.6 (4.4– 36.4) | <0.001* | 13.0 (4.4 –38.1) | < 0.001* | |
| Regimen containing (BDQ+ Lzd)/Lzd | 85 (92.4)/13 (56.5) | 9.3(3.0 –28.9) | <0.001* | 13.7 (1.8–103.8) | 0.01* | |
| Regimen containing (BDQ+ FQs)/FQs | 19 (82.6)/45(57.7) | 3.5 (1.1–11.2 ) | 0.03* | 2.5 (0.5–12.6 ) | 0.27 | |
| Regimen containing (BDQ+Cs)/Cs | 71(92.2)/58 (63.7) | 6.7 (2.6–17.2) | < 0.001* | 13.1 (3.7–45.7) | < 0.001* | |
| BDQ+injectable agents/injectable agents | 52 (96.3/60) (65.9) | 13.4 (3.1–58.9) | < 0.001* | 12.1 (2.7–53.7) | 0.001* | |
| BDQ + Lzd+ FQs/Lzd+FQs | 14 (82.4)/9 (50.0) | 4.7 (0.1–22.0) | 0.08 | 15.2 (1.42–163.3) | 0.03* | |
| BDQ+ Lzd+ FQs+ Cfz/Cfz+ Lzd+ FQs | 15 (88.2)/3 (33.3) | 15.0 (2.0–113.6) | 0.01* | 38.9 (1.9–817.1) | 0.02* | |
TB tuberculosis, RR rifampicin-resistant, MDR multidrug-resistant, XDR extensively drug-resistant, 95%CI 95% confidence interval, OR odds ratio
* the differences had statistical significance (p < 0.05)