Table 5.
Univariate and multivariate analysis of independent predictors for reversion to positive culture
| Independent factors | Reversion to positive culture | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| OR (95%CI) | p value | OR (95%CI) | p value | |||
| Age | – | – | ||||
| < 35 years | 5 (6.0) | – | – | – | – | |
| 35–60 years | 15 (15.0) | 2.8 (1.0–8.0) | 0.05 | – | – | |
| ≥ 60 years | 1 (5.6) | 1.0 (0.1–8.5) | 0.94 | – | – | |
| Type of drug resistance | – | – | ||||
| RR | 1 (12.5) | – | – | – | – | |
| MDR | 11 (7.7) | 0.6 (0.1–5.2) | 0.63 | – | – | |
| XDR | 9 (17.3) | 1.5 (0.2–13.4) | 0.73 | – | – | |
| History of TB treatment (new/previously treated) | 2 (10.5)/19 (10.4) | 1.0 (0.2–4.7) | 0.99 | – | – | |
| Cavitary disease at baseline (yes/no) | 18 (12.9)/3 (5.6) | 0.4 (0.1–1.4) | 0.14 | |||
| Concomitant diabetes (yes/no) | 3 (10.3)/18 (10.4) | 1.0 (0.3–3.7) | 0.99 | |||
| Gender (male/female) | 20 (13.5)/1 (1.9) | 8.1 (1.1–62.1) | 0.02 | 1.2 (0.4–4.1) | 0.71 | |
| Treatment regimen (bedaquiline/non-bedaquiline) | 3 (2.9)/18 (18.0) | 0.1 (0.0–0.5) | < 0.001 | 0.1 (0.0–0.5) | 0.002* | |
| Regimen containing (BDQ+ Cfz) /Cfz | 5 (5.4)/18 (36.0) | 0.1(0.0–0.3) | < 0.001 | 0.1 (0. 0–0.4) | < 0.001* | |
| Regimen containing (BDQ+ Lzd)/Lzd | 5 (5.4)/7(30.4) | 0.1 (0.0–0.5) | < 0.001 | 0.1(0.0–0.5) | 0.001* | |
| Regimen containing (BDQ+ FQs)/FQs | 1(4.3)/19(24.4) | 0.1 (0.0–1.1) | 0.03 | 0.00 (–) | 1.0 | |
| Regimen containing (BDQ+Cs)/Cs | 5 (6.5)/24 (26.4) | 0.2 (0.1–0.5) | 0.00 | 0.2(0.0–0.5) | 0.001* | |
| BDQ+injectable agents/injectable agents | 4(7.4)/21(23.1) | 0.3 (0.1–0.8) | 0.016 | 0.1 (0.0–0.5) | 0.006* | |
TB tuberculosis, RR rifampicin-resistant, MDR multidrug-resistant, XDR extensively drug-resistant, 95%CI 95% confidence interval, OR odds ratio
* the differences had statistical significance (p < 0.05)