Table 3.
The univariate and multivariate analysis of hsa-miR-765 and clinicopathological features of HCC patients
| Characteristics | Total(N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| T stage | 371 | ||||
| T1 & T2 | 279 | Reference | |||
| T3 & T4 | 93 | 2.617 (1.834–3.736) | < 0.001 | 1.844 (0.250–13.590) | 0.548 |
| N stage | 260 | ||||
| N0 | 256 | Reference | |||
| N1 | 4 | 2.051 (0.503–8.372) | 0.317 | ||
| M stage | 275 | ||||
| M0 | 271 | Reference | |||
| M1 | 4 | 4.083 (1.284–12.990) | 0.017 | 2.005 (0.614–6.544) | 0.249 |
| Pathologic stage | 350 | ||||
| Stage I & Stage II | 261 | Reference | |||
| Stage III & Stage IV | 90 | 2.519 (1.731–3.665) | < 0.001 | 1.452 (0.198–10.648) | 0.713 |
| Histologic grade | 370 | ||||
| G1&G2 | 232 | Reference | |||
| G3&G4 | 139 | 1.068 (0.744–1.533) | 0.721 | ||
| Gender | 374 | ||||
| Female | 119 | Reference | |||
| Male | 256 | 0.799 (0.558–1.143) | 0.219 | ||
| Age | 374 | ||||
| ≤ 60 | 178 | Reference | |||
| > 60 | 196 | 1.222 (0.860–1.738) | 0.263 | ||
| Vascular invasion | 319 | ||||
| No | 208 | Reference | |||
| Yes | 112 | 1.337 (0.882–2.028) | 0.172 | ||
| hsa-miR-765 | 374 | ||||
| Low | 188 | Reference | |||
| High | 187 | 1.437 (1.012–2.043) | 0.043 | 1.579 (1.011–2.466) | 0.044 |