Table 1.
Genetic correlation between human blood metabolites and pulmonary embolism (P value < 0.05)
| Blood metabolites | Gene | Genetic Correlation | p values | |
|---|---|---|---|---|
| pulmonary embolism | 1-stearoylglycerophosphoethanolamine | LIPC | 0.0047 | 0.008 |
| X-12100--hydroxytryptophan | USE1 | 0.0045 | 0.0435 | |
| N1-methyladenosine | SPATA20 | 0.185 | 0.0439 | |
| valine | GYPA | 0.1569 | 0.0274 | |
| X-12029 | CRISP2 | 0.0134 | 0.0073 | |
| X-11412 | AT1B2 | 0.1288 | 0.0476 |
GWAS data for pulmonary embolism were derived from a European cohort study of 448,312 pulmonary embolism cases and 3952 controls. GWAS data for human blood metabolites were also derived from a European cohort study involving 529 metabolites in plasma or serum of 7824 adults. We used LD score regression software (https://github.com/bulik/ldsc) to complete genetic correlation analysis between pulmonary embolism and blood metabolites