Table 1.
Demographic and clinical features
| Healthy control | Parkinson’s disease | P | Healthy control | Parkinson’s disease | |
|---|---|---|---|---|---|
| High-affinity binders | Mix-affinity binders | ||||
| No. | 22 | 22 | – | 1 | 2 |
| Age | 58.91 ± 9.78 | 59.27 ± 11.96 | 0.913 | 59 | 60, 66 |
| Gender (M/F) | 10/12 | 15/7 | 0.128 | 0/1 | 1/1 |
| MDS-UPDRS III scores | 0.41 ± 1.33 | 21.23 ± 10.14 | < 0.0001 | 0 | 11, 5 |
| GDS | 6.09 ± 6.29 | 6.27 ± 5.44 | 0.680a | 2 | 7, 16 |
| MMSE | 28.45 ± 1.79 | 26.95 ± 6.35 | 0.236 | 30 | 28, 30 |
| RBDQ-HK | 6.95 ± 8.28 | 12.73 ± 14.71 | 0.163a | 5 | 4, 9 |
| LEDD | – | 508.33 ± 239.7 | – | – | 0, 0 |
| Dose (18F-FP-DTBZ) | 283.82 ± 60.34 | 298.00 ± 67.01 | 0.469 | 346 | 267, 253 |
| Dose (18F-PRB06) | 348.14 ± 19.61 | 353.35 ± 21.54 | 0.430 | 360 | 373, 332 |
GDS Geriatric Depression Scale, MDS-UPDRS III MDS-Unified Parkinson’s Disease Rating Scale motor scores, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, P p-value, RBDQ-HK REM Sleep Behavior Disorder Questionnaire-Hong Kong, SUVR standardized uptake value ratio
aCalculated with Mann–Whitney test