Table 1.

Clinical and laboratorial features of the three homozygous patients.

Parameters	Mean ± s.d.	Normal range
Age (years)	38.7 ± 6
BMI (kg/m2)	44.5 ± 7.1	18.5–24.9
Weight (kg)	134.6 ± 16.9
Leptin (ng/mL)	80 ± 34.6	2.0–60.0
FSH (mUI/mL)	15.6 ± 3.7	1.5–12.4
LH (mUI/mL)	12.3 ± 2.2	1.7–8.6
Estradiol (pg/mL)	36.4 ± 16.1	11–44
Total testosterone (ng/dL)	445 ± 401	249–836
Insulin levels (mU/L)	26.4 ± 15.8	5–10
Glycemia (mg/dL)	112.1 ± 33.9	80–110
TSH (mIU/L)	2.03 ± 1.4	0.5–4.5
T4L (ng/dL)	0.97 ± 1.0	0.8–1.8
T3L (pg/mL)	2.98 ± 0.59	2.3–4.2
HbA1c (%)	5.8 ± 1.0	4.0–5.6
ACTH (pg/mL)	41.4 ± 18.9	10–60
IGF1 (ng/mL)	140.9 ± 33.2	72–246