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. 2021 Mar 13;88(1):130–140. doi: 10.1016/j.bjorl.2021.02.008

Table 5.

Cumulative doses of cisplatin and carboplatin and medications used concomitantly with chemotherapy.

Authors (year) Cumulative dose Cumulative dose Cumulative dose Concomitant medications
Cisplatin (n) Carboplatin (n) Cisplatin + carboplatin (n)
Einarsson et al.27 (2010) NHG: varied from 180 to 690 mg/m2 (n = 5) – HLG: cisplatin = 320 mg/m2, carboplatin = 3000 mg/m2 (n = 1) NCI
HLG: ranged from 360 to 500 mg/m2 (n = 8)
Clemens et al.28 (2016) Ranged from 45 to 950 mg/m2 (n = 276) Ranged from 104 to 9436 mg/m2 (n = 112) Cisplatin = ranged from 80 to 570 mg/m2, carboplatin = ranged from 400 to 6043 mg/m2 (n = 63) Vancomycin, gentamicin, tobramycin, furosemide (n = 285)
Clemens et al.29 (2017)a Ranged from 180 to 900 mg/m2 (n = 46) Ranged from 1288 to 3230 mg/m2 (n = 2) Cisplatin = ranged from 300 to 570 mg/m2, carboplatin = ranged from 992 to 3938 mg/m2 (n = 13) NI

Source: Einarsson et al.27 and Clemens et al.28, 29

N, sample number; NHG, normal hearing group; HLG, hearing loss group; NI, no information; mg/m2: milligram per square meter.

a

Only subjects with hearing loss were included.