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. 2022 Aug 22;20(4):358–367. doi: 10.1089/lrb.2021.0031

FIG. 3.

FIG. 3.

Lipid handling and instances of chylothorax in VD mice. (A) Triglyceride uptake and clearance curves of WT and VD Adipo-VD mice on (A) standard HFD (n = 8 WT, 6 VD), (B) HUSFD (n = 4 WT, 6 VD), and (C) HSFD (n = 4 WT, 2 VD). (D) Calculated appearance rate of oral triglyceride load in the plasma. (E) The calculated area under the curve for triglyceride uptake and clearance experiments. (F) Mesenteric vessel-associated adipose streaks representative images for standard chow, HFD (n = 8 WT, 7 VD), HUSFD (n = 5 WT, 5 VD), and HSFD (n = 4 WT, 2 VD). Scale bars = 5 mm. (G) Quantified average width of mesenteric vessel-associated adipose per each diet condition. (H) Survival curves of VD mice provided 600 mg/kg doxycycline in 60% kcal from fat HFD enriched for HUSFD, HFD, and HSFD. (I) Incidence of chylous events identified through 2 months of HFD feeding in VD mice provided HUSFD (blue, left), HFD (black, center), or HSFD (red, right). *Indicates p < 0.05 compared with WT; #Indicates p < 0.05 relative to standard HFD for the same genotype.