Table 1.

Multidomains of clinical profile, constructs and assessments

Domains	Constructs	Assessments
Clinical presentation	Mental disorder diagnoses	The DSM-5 matched Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS)
	Severity of symptom clusters
	Severity of depressive symptoms	17-item Hamilton Depression Rating Scale (HAMD-17)
		Montgomery-Åsberg Depression Rating Scale (MADRS)
	Severity of anxiety symptoms	The Hamilton Anxiety Scale (HAMA)
	Severity of hypomanic/manic symptoms	Young Mania Rating Scale (YMRS)
	Severity of psychotic symptoms	six-item version of the Positive and Negative Syndrome Scale (PANSS-6)
	High-risk mental states assessment	Bipolar Prodrome Symptom Scale-Full Prospective (BPSS-FP)
		Structured Interview for Prodromal Syndromes (SIPS)
	Sleep quality and circadian rhythm	Pittsburgh Sleep Quality Index (PSQI), Morningness-Eveningness Questionnaire (MEQ)
	Self-injury and suicidal thoughts and behaviours	Ottawa Self-Injury Inventory (OSI), Columbia Suicide Severity Rating Scale (C-SSRS)
Tobacco/alcohol and substance use	Current and previous smoking status	Smoking questionnaire
		Fagerström Test for Nicotine Dependence (FTND)
	Alcohol and substance use in the life time and last 3 months	Self-designed alcohol use and substance use questionnaire
Physical health comorbidities and family history	Previous and current physical illness of patients	Self-made case report form
	Family history of hypertension, diabetes and thyroid disease
	Family histories of mental illnesses	Family Interview for Genetic Studies (FIGS)
Treatment-related information	Side effects of antidepressants and adherence	Side effects of antidepressants and adherence
	Treatment response	Reduction rate of HAMD-17
		Clinical Global Impressions-Severity of Illness (CGI-S)