Table 2.
Standard assessments and detailed assessments of objective measures
Objective measures | Standard assessments | Detailed assessments |
Neurocognitive function | MATRICS Consensus Cognitive Battery (MCCB) | |
Information processing speed | Trail Making Test Part A | |
Brief Assessment of Cognition in Schizophrenia: Symbol Coding (BACS-SC) | ||
Category fluency | ||
Verbal learning | Hopkins Verbal Learning Test (HVLT) | |
Visual learning | Brief Visuospatial Memory Test-Revised (BVMT-R) | |
Working memory | Wechsler Memory Scale Spatial span | |
Anthropometric measurement | Anthropometric measurement | Height |
Weight | ||
Waist circumference | ||
Body mass index | ||
Upper arm circumference | ||
Blood pressure | ||
Plasma | Metabolic and immune markers | Blood pathology analysis |
Full blood count | ||
Urea, triglycerides, cholesterol, apolipoprotein | ||
Thyroid function | ||
Fasting blood glucose, insulin, β-hydroxybutyric acid | ||
More extensive molecular biologic marker screening | DNA, RNA, neuroimmune cytokines, protein, exosomes, etc | |
Faeces | Intestinal flora | Abundance of microbial compositions, Alpha-diversity |
EEG | Resting-state EEG | Delta, Theta, Alpha, Beta and Gamma bands |
Brain structure and function | Brain structure | Cortical thickness, surface area, cortical and subcortical volume and mean curvature |
Brain function | Metrics of local brain activity: ALFF, ReHo, DC, VMHC, etc | |
Functional connectivity: static and dynamic FC | ||
Global and Network Metrics: small world, global efficiency, rich-club, clustering coefficient, shortest path length, betweenness-centrality local efficiency, etc |
ALFF, amplitude of low-frequency fluctuation; DC, degree centrality; EEG, electroencephalography; FC, functional connectivity; MATRICS, Measurement and Treatment Research to Improve Cognition in Schizophrenia; ReHo, regional homogeneity; VMHC, voxel-mirrored homotopic connectivity.