Table 2.

Multivariable Cox regression for comparing immunosuppressed vs immunocompetent group based on calendar time

	SARS-CoV-2 infections		COVID-19 hospitalization
Variable	HR (95% CI)	p-value	HR (95% CI)	p-value
Unvaccinated (Immunosuppressed vs Immunocompetent)	1.398 (1.068 – 1.829)	0.0075	0.951 (0.435 – 2.080)	0.9984
Fully vaccinated (Immunosuppressed vs Immunocompetent)	2.173 (1.690 – 2.794)	< 0.0001	4.861 (2.238 – 10.56)	< 0.0001
Immunocompetent (Fully vaccinated vs Unvaccinated)	0.354 (0.319 – 0.392)	< 0.0001	0.105 (0.067 – 0.162)	< 0.0001
Immunosuppressed (Fully vaccinated vs Unvaccinated)	0.550 (0.387 – 0.781)	0.0001	0.534 (0.196 – 1.452)	0.3724
Age
- Under 31	Ref	Ref	Ref	Ref
- 31 – 50	1.497 (1.351 – 1.659)	< 0.0001	1.560 (0.970 – 2.509)	0.0668
- 51 – 64	1.481 (1.324 – 1.657)	< 0.0001	3.119 (1.961 – 4.961)	< 0.0001
- Over 65	1.243 (1.096 – 1.411)	0.0007	4.550 (2.829 – 7.320)	< 0.0001
Gender
- Female	Ref	Ref	Ref	Ref
- Male	0.864 (0.804 – 0.929)	< 0.0001	1.419 (1.109 – 1.816)	0.0054
Race
- Caucasian	Ref	Ref	Ref	Ref
- African American	0.867 (0.774 – 0.972)	0.0147	1.408 (0.995 – 1.991)	0.0531
- Other/unknown	0.548 (0.481 – 0.624)	< .0001	0.875 (0.570 – 1.341)	0.5397
Charlson Comorbidity Index
- >= 5	Ref	Ref	Ref	Ref
- 3 – 4	0.876 (0.712 – 1.078)	0.2118	0.478 (0.290 – 0.791)	0.0040
- 1 – 2	0.699 (0.587 – 0.832)	<0.0001	0.433 (0.293 – 0.640)	< 0.0001
- 0	0.468 (0.396 – 0.554)	<0.0001	0.187 (0.126 – 0.276)	<0.0001