Figure 1.

Kaplan-Meier mortality estimates according to combined CHIP and AgeAccelHG status. CHIP± indicates the presence or absence of clonal hematopoiesis of indeterminate potential. AgeAccelHG± indicates whether individuals had positive age acceleration in both Hannum and GrimAge estimators (+) or in only one or neither estimators (−). The plot is based on a Cox proportional hazards model with delayed entry (origin date in the individuals’ birth date and entry date at date of blood sampling), hence the x-axis shown in the plot starts at blood sampling. One twin pair of the present study population died very soon after blood sampling; this twin pair was removed for the plot, as a gap in analysis time, would otherwise have distorted the dimensions of the plot. The estimates obtained for all individuals (N = 224) and leaving out the twin pair (N = 222) were identical (data not shown). AgeAccelHG = age acceleration defined by both the Hannum and GrimAge estimators; CHIP = clonal hematopoiesis of indeterminate potential.