Table 1.
Individual-level Analysis of CHIP Mutation Status and Age Acceleration by Linear Regression Analysis
| AgeAccel | Coef. (95% CI) | P | |
|---|---|---|---|
| Any CHIP mutation (N = 308 individuals) | Horvath | 0.98 (−0.67 to 2.63) | 0.243 |
| IEAA | 1.40 (−0.01 to 2.81) | 0.052 | |
| Hannum | 1.04 (−0.25 to 2.33) | 0.112 | |
| EEAA | 1.06 (−0.56 to 2.69) | 0.197 | |
| PhenoAge | 0.51 (−1.32 to 2.35) | 0.582 | |
| GrimAge | 0.82 (−0.14 to 1.78) | 0.094 | |
| TET2 mutation (N = 239 individuals) | Horvath | 1.12 (−1.16 to 3.39) | 0.333 |
| IEAA | 1.09 (−0.84 to 3.02) | 0.266 | |
| Hannum | 3.04 (1.07 to 5.01) | 0.003 | |
| EEAA | 3.61 (1.17 to 6.06) | 0.004 | |
| PhenoAge | 1.61 (−0.77 to 3.98) | 0.183 | |
| GrimAge | 1.48 (0.15 to 2.81) | 0.029 | |
| DNMT3A mutation (N = 244 individuals) | Horvath | 1.03 (−0.86 to 2.93) | 0.283 |
| IEAA | 1.93 (0.15 to 3.72) | 0.034 | |
| Hannum | −0.58 (−2.11 to 0.95) | 0.456 | |
| EEAA | −1.13 (−3.09 to 0.82) | 0.255 | |
| PhenoAge | 0.01 (−2.35 to 2.37) | 0.992 | |
| GrimAge | 0.68 (−0.81 to 2.16) | 0.369 |
Statistically significant findings (P < 0.05) are indicated in bold.
AgeAccel = epigenetic age acceleration; CHIP = clonal hematopoiesis of indeterminate potential; Coef. = coefficient (beta value); EEAA = extrinsic epigenetic age acceleration; IEAA = intrinsic epigenetic age acceleration.