Table 2.
Individual-level Analysis of VAF and Age Acceleration by Linear Regression Analysis
| AgeAccel | Coef. (95% CI) | P | |
|---|---|---|---|
| Any CHIP mutation (N = 116 individuals) | Horvath | 5.87 (1.47 to 10.27) | 0.009 |
| IEAA | 4.72 (0.57 to 8.88) | 0.026 | |
| Hannum | 6.38 (3.11 to 9.66) | 0.00020 | |
| EEAA | 7.97 (4.03 to 11.90) | 0.00012 | |
| PhenoAge | 4.92 (−0.44 to 10.29) | 0.071 | |
| GrimAge | 1.84 (−0.78 to 4.47) | 0.166 | |
| TET2 mutation (N = 47 individuals) | Horvath | 4.11 (−1.33 to 9.54) | 0.135 |
| IEAA | 2.14 (−2.52 to 6.80) | 0.359 | |
| Hannum | 4.85 (−0.33 to 10.03) | 0.066 | |
| EEAA | 6.32 (0.32 to 12.33) | 0.039 | |
| PhenoAge | −0.16 (−6.22 to 5.90) | 0.958 | |
| GrimAge | −1.35 (−4.88 to 2.19) | 0.447 | |
| DNMT3A mutation (N = 52 individuals) | Horvath | 9.64 (1.97 to 17.31) | 0.015 |
| IEAA | 9.57 (2.09 to 17.04) | 0.013 | |
| Hannum | 5.65 (0.51 to 10.78) | 0.032 | |
| EEAA | 6.45 (0.11 to 12.78) | 0.046 | |
| PhenoAge | 8.24 (−0.84 to 17.32) | 0.074 | |
| GrimAge | 2.31 (−2.40 to 7.02) | 0.329 |
Statistically significant findings (P < 0.05) are indicated in bold.
AgeAccel = epigenetic age acceleration; CHIP = clonal hematopoiesis of indeterminate potential; Coef. = coefficient (beta value); EEAA = extrinsic epigenetic age acceleration; IEAA = intrinsic epigenetic age acceleration; VAF = variant allele frequency.