Table 3.
Intrapair Analysis of CHIP Mutation Status and Age Acceleration by Linear Regression Analysis in Twin Pairs Discordant for CHIP Mutation Status
| AgeAccel | Coef. (95% CI) | P | |
|---|---|---|---|
| Any CHIP mutation (N = 72 twin pairs) | Horvath | −0.11 (−1.83 to 1.61) | 0.898 |
| IEAA | 0.54 (−0.88 to 1.96) | 0.448 | |
| Hannum | 1.62 (0.19–3.06) | 0.027 | |
| EEAA | 1.64 (−0.19 to 3.47) | 0.078 | |
| PhenoAge | 0.87 (−1.49 to 3.22) | 0.465 | |
| GrimAge | 0.94 (−0.18 to 2.06) | 0.099 | |
| TET2 mutation (N = 30 twin pairs) | Horvath | −0.08 (−3.17 to 3.02) | 0.960 |
| IEAA | 0.90 (−1.46 to 3.25) | 0.443 | |
| Hannum | 2.77 (−0.03 to 5.57) | 0.052 | |
| EEAA | 2.71 (−0.86 to 6.29) | 0.131 | |
| PhenoAge | 1.51 (−3.34 to 6.35) | 0.529 | |
| GrimAge | 1.24 (−0.60 to 3.07) | 0.179 | |
| DNMT3A mutation (N = 33 twin pairs) | Horvath | −0.26 (−2.98 to 2.46) | 0.846 |
| IEAA | 0.91 (−1.31 to 3.13) | 0.410 | |
| Hannum | 0.77 (−1.60 to 3.13) | 0.514 | |
| EEAA | 0.62 (−2.50 to 3.74) | 0.689 | |
| PhenoAge | −0.59 (−4.72 to 3.54) | 0.774 | |
| GrimAge | 2.18 (0.05–4.30) | 0.045 |
Statistically significant findings (P < 0.05) are indicated in bold.
AgeAccel = epigenetic age acceleration; CHIP = clonal hematopoiesis of indeterminate potential; Coef. = coefficient (beta value); EEAA = extrinsic epigenetic age acceleration; IEAA = intrinsic epigenetic age acceleration.