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. 2022 Aug 15;15:953066. doi: 10.3389/fnmol.2022.953066

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Copyright © 2022 Chen, Oh and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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p11 as a functional modulator of its binding partners at the plasma membrane and in the nucleus. p11 dimer or p11/AnxA2 heterotetrameric complex regulates serotonin, glutamate, or calcium signaling by increasing levels of 5-HTRs (A), mGluR5 (B) or L-type VGCCs (C) at the plasma membrane. The heterotetrameric p11/AnxA2 complex also binds to Smarca3 (D) or Supt6h (E) and regulates Smarca3- or Supt6h-mediated chromatin remodeling, epigenetic modifications, and gene transcription. These cell surface and nuclear actions underlie depressive or antidepressant-like behavioral effects of genetic modulations of p11 and its binding partners. This figure was created with BioRender.com.