Table 2.
Logistic regression model showing the predictors of SABA overprescribing (≥6 SABA in the previous 12 months) for adults with asthma
| Variables | Number | Multivariate logistic modela,b | |||
|---|---|---|---|---|---|
|
| |||||
| SABA <6 | SABA ≥6 | OR | 95% CI | P-value | |
| Age | |||||
| Adult | 13 098 | 5970 | |||
| Older adult (>60) | 2686 | 2139 | 1.34 | 1.24 to 1.45 | <0.01 |
|
| |||||
| Sex | |||||
| Male | 6392 | 3430 | |||
| Female | 9393 | 4679 | 0.85 | 0.90 to 0.80 | <0.01 |
|
| |||||
| Ethnicity | |||||
| White | 6066 | 3297 | |||
| Mixed | 6082 | 3297 | 0.87 | 0.75 to 1.00 | 0.39 |
| Asian or Asian British | 1568 | 655 | 1.13 | 1.05 to 1.21 | 0.02 |
| Black | 778 | 352 | 0.94 | 0.84 to 1.06 | 0.15 |
| Other | 186 | 81 | 1.01 | 0.76 to 1.36 | 0.03 |
| Not stated/unclassified | 1104 | 427 | 0.84 | 0.74 to 0.96 | 0.03 |
|
| |||||
| Prescription type | |||||
| Repeat | 8671 | 6392 | |||
| Acute and automatic | 7074 | 1513 | 0.29 | 0.27 to 0.31 | <0.01 |
| Repeat dispensed | 39 | 204 | 6.52 | 4.64 to 9.41 | <0.01 |
|
| |||||
| Smoking | |||||
| Never | 10 512 | 4848 | |||
| Current | 2395 | 1524 | 1.51 | 1.38 to 1.63 | <0.01 |
| Ex-smoker | 2840 | 1716 | 1.21 | 1.13 to 1.32 | <0.01 |
|
| |||||
| Asthma step | |||||
| Step 1 | 2485 | 670 | |||
| Step 2 | 6218 | 3289 | 1.79 | 1.62 to 1.97 | <0.01 |
| Step 3 | 1864 | 1826 | 2.87 | 2.56 to 3.21 | <0.01 |
| Step 4+5 | 136 | 323 | 4.99 | 3.96 to 6.30 | <0.01 |
| Unknown | 5082 | 2001 | 1.19 | 1.05 to 1.35 | <0.01 |
|
| |||||
| Oral steroid | |||||
| Zero | 13 188 | 5955 | |||
| 1 | 1851 | 1139 | 1.35 | 1.21 to 1.45 | <0.01 |
| 2 | 392 | 412 | 2.67 | 2.48 to 2.71 | <0.01 |
| ≥3 | 354 | 603 | 2.90 | 2.46 to 3.31 | <0.01 |
|
| |||||
| Physical comorbidities | |||||
| 0 | 5401 | 2044 | |||
| 1 | 6307 | 2802 | 1.07 | 1.00 to 1.16 | 0.05 |
| 2–3 | 3448 | 2591 | 1.58 | 1.47 to 1.73 | <0.01 |
| ≥4 | 628 | 672 | 1.86 | 1.61 to 2.13 | <0.01 |
|
| |||||
| Mental comorbidities | |||||
| 0 | 10 630 | 4795 | |||
| 1 | 2796 | 1612 | 1.19 | 1.10 to 1.28 | <0.01 |
| 2 | 2204 | 1519 | 1.32 | 1.22 to 1.44 | <0.01 |
| 3 | 154 | 183 | 2.29 | 1.80 to 2.91 | <0.01 |
a
This model is adjusted by Index of Multiple Deprivation score.
b
This model is a mixed-effect multivariate logistic regression, which includes clustering based on the practice (Newham, Tower Hamlet and Waltham Forest). The adjusted interclass correlation coefficient of this variable is 0.006, which is negligible. CI = confidence interval. OR = odds ratio. SABA = short-acting beta-agonist.