TABLE 1.

Human conditions with reported changes in MANF and CDNF expression

Disease	Change	Reference
Atrial Fibrillation	Decreased MANF mRNA and protein in serum	Wang et al 2019
Diabetes Type 1	Increased MANF protein in plasma	Galli et al 2016
Diabetes Type 2	Increased MANF protein in plasma	Wu et al 2017, Fu et al 2020
Fasting	Increased MANF protein in plasma	Galli et al 2019a
Hepatocellular carcinoma	Increased MANF mRNA and protein in tissue	He et al 2020a
Hyperlipidemia	Increased MANF protein in serum	Fu et al 2020
Nonalcoholic Steatohepatitis	Decreased MANF protein in serum	Sousa-Victor et al 2019
Parkinson’s disease	Increased MANF protein in plasma	Galli et al 2019b
Parkinson’s disease	Increased CDNF protein in hippocampus	Virachit et al 2019
Physiological ageing	Decreased MANF protein in plasma	Sousa-Victor et al 2019
Polycystic ovary syndrome	Decreased MANF protein in plasma	Wei et al 2020
Proliferative diabetic retinopathy	Increased MANF protein in vitreous	Gao et al 2017
Retinal detachment	Increased MANF protein in vitreous	Gao et al 2017
Rheumatoid arthritis	Increased MANF mRNA in white blood cells	Chen et al 2015
Stroke	Decreased CDNF mRNA levels in blood platelets	Joshi et al 2020
Systemic lupus erythematosus	Increased MANF mRNA in white blood cells	Chen et al 2015