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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: Cell Host Microbe. 2022 Mar 9;30(3):277–278. doi: 10.1016/j.chom.2022.02.009

Fig 1: Spatial organization of gut microbiota influence immunity, epithelial barrier function and social behavior in mice.

Fig 1:

Sequencing of ribosomal DNA on luminal and mucosal fungi identified diverse luminal fungal communities but comparatively less diverse mucosa-associated fungal (MAF) communities in the gut. MAF but not luminal fungi could promote barrier function through induction of Type 17 cytokines (IL-22 and IL-17) by CD4+ T cells, which protect mice against DSS-induced intestinal epithelial injury and also Citrobacter rodentium bacterial infection. MAF also influences neuroimmune modulation of mouse social behavior by virtue of IL-17 receptor signaling in neurons. Image created with BioRender.com. Images of mice was purchased from ©www.gograph.com / Kudryashka.