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. Author manuscript; available in PMC: 2022 Aug 29.
Published in final edited form as: Cell Res. 2010 Sep 7;20(11):1201–1215. doi: 10.1038/cr.2010.128

Figure 2.

Figure 2

Absence of BRCA1 favors open chromatin structure and increases expression of protooncogenes. (A) Altered epigenetic modifications in BRCA1-mutant mammary gland and mammary tumors revealed by western blots. (B, C) BRCA1 deficiency causes abnormal expression of genes involved in genomic imprinting in spermatocytes (Sp) (B) and mammary tissue and tumor (C) revealed by RT-PCR. (D–F) Relative expression of protooncogenes C-Fos (D), Ha-Ras (E), and C-Myc (F) in BRCA1-mutant mammary gland (MG) and mammary tumors revealed by real-time PCR. (G) Semiquantitative analysis of promoter methylation of protooncogenes by methylation-specific PCR. * Represents P < 0.05 of Student’s t-test.