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BRCA1 regulates DNMT1 expression on its promoter. (A) Activities of three Dnmt1 luciferase reporters (D1, D2, and D4) in relation to pGL3 vector, which were set at 1, in neu cells upon shRNA-mediated downregulation of BRCA1. (B) Luciferase activity of D1 reporter in Tet-regulated UBR-60 cells. (C, D) ChIP analysis of histone modifications of the human (C) and mouse (D) DNMT1 promoter. * Represents P < 0.05 of Student’s t-test.
