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. Author manuscript; available in PMC: 2022 Aug 29.
Published in final edited form as: Cell Res. 2010 Sep 7;20(11):1201–1215. doi: 10.1038/cr.2010.128

Figure 7.

Figure 7

Expression of DNMT1 and BRCA1 in human primary breast cancers. (A) BRCA1 and DNMT1 protein levels in 31 human sporadic breast cancers. Immunohistochemical staining of BRCA1 and DNMT1 protein levels were detected by using antibodies against BRCA1 and DNMT1. Intensity of the staining was scored by division into 10 arbitrary units based on the graded intensities. The x axis and y axis are for DNMT1 and BRCA1 levels, respectively. (B) Examples of immunohistochemical staining showing positive correlation between expression levels of BRCA1 and DNMT1 in human breast cancers. (C) Immunofluorescent images of varying methylation levels after 5-methyl cytosine staining, which was also proportional to levels of BRCA1 staining in all analyzed samples.