Table 1:
Predicted upstream regulator gene pathways affected by PCB126 treatment of preadipocytes at different timepoints of 9 hours, 1 day, or 3 days. The over-representation p-value is based on the number of differentially expressed genes considered downstream of the upstream regulator gene. Fdr≤0.05
| 9-Hour | 1-Day | 3-Day | |||
|---|---|---|---|---|---|
| Gene symbol | pv_comb_p_fdr | Gene symbol | pv_comb_p_fdr | Gene symbol | pv_comb_p_fdr |
| AHR | 0.005954545 | SREBF2 | 3.56E-09 | IL1B | 5.93693E-05 |
| HGF | 0.012824388 | NFYB | 1.32184E-05 | GAST | 0.002052121 |
| GAST | 0.012824388 | NFYC | 1.32184E-05 | IL33 | 0.002052121 |
| PROK1 | 0.012824388 | NFYA | 1.94097E-05 | ATF4 | 0.002052121 |
| TNF | 0.012824388 | IL17A | 4.3981E-05 | IRF9 | 0.006077495 |
| TLR2 | 0.012824388 | IL1B | 5.65353E-05 | IL17A | 0.006552089 |
| RELA | 0.015822055 | AHR | 0.00025815 | OSM | 0.013833113 |
| IL1B | 0.015822055 | CCL2 | 0.00025815 | TNF | 0.013833113 |
| IL6 | 0.015822055 | GAST | 0.000921071 | BMP7 | 0.023533496 |
| CSF2 | 0.015822055 | TNF | 0.000988789 | NFKB1 | 0.023533496 |