Figure 2.

Miami plot depicting the APOE-stratified GWAS results. The upper panel shows the GWAS results comparing APOE ε4-negative DLB cases with APOE ε4-negative controls (n = 1286 cases versus 2271 controls). The bottom panel shows the association test results comparing APOE ε4-positive DLB cases with APOE ε4-positive controls (n = 1180 cases versus 657 controls). The x-axis depicts the chromosomal position for 22 autosomes in hg38 and the y-axis denotes the association P-values on a −log₁₀ scale. The dotted, horizontal line indicates the conservative Bonferroni threshold for genome-wide significance. Suggestive variants are indicated by orange dots, while red dots highlight genome-wide significant associations.