Table 4.

Odds of Parkinson’s disease or parent with Parkinson’s disease in PRKN heterozygous mutation carriers in UK Biobank

Mutation	Mut_Cases	Mut_controls	NoMut_Cases	NoMut_controls	Odds	CI	P-value
For single PRKN mutation carriers
Odds of Parkinson’s disease in UK Biobank participants with WES and array (n = 200 606)
Frameshift_SNP	2	683	1372	198 549	0.42	0.05–1.54	0.35
AnySNP	15	2517	1359	196 715	0.86	0.48–1.43	0.71
AnyMut	23	3648	1351	195 584	0.91	0.58–1.38	0.76
Odds of parent with Parkinson’s disease in UK Biobank participants with WES and array (n = 200 606)
Frameshift_SNP	29	656	7465	192 456	1.14	0.76–1.65	0.48
AnySNP	104	2428	7390	190 684	1.11	0.90–1.35	0.32
AnyMut	152	3519	7342	189 593	1.12	0.94–1.31	0.19
Odds of Parkinson’s disease in NIH–PD + AMP–PD (n = 2862 cases versus 1099 controls)
Frameshift_SNP	8	1	2853	1098	3.08	0.41–136.70	0.46
AnySNP	27	7	2834	1092	1.49	0.63–4.05	0.44
AnyCNV	30	10	2831	1089	1.15	0.55–2.66	0.86
AnyMut	57	17	2804	1082	1.29	0.74–2.38	0.43
For double PRKN mutation carriers
Odds of Parkinson’s disease in UK Biobank Participants with WES and microarray (n = 200 606)
AnyMut	2	22	1351	195 584	13.16	1.50–53.57	0.012
Odds of Parkinson’s disease in NIH–PD + AMP–PD (n = 2862 cases versus 1099 controls)
AnyMut	20	0	2804	1082	Infinity	1.90–infinity	0.0020