Figure 1.

Effect of ipragliflozin (Ipra), furosemide (Furo), or vehicle (Veh) administered for 7 days in nondiabetic Sprague–Dawley rats on change in body weight (A), serum creatinine (B), blood urea nitrogen (C), and change in total body water (D). Veh: 0.5% methylcellulose solution, Ipra: 5 mg/kg body wt in 0.5% mehylcellulose, Furo: 50 mg/kg body wt in 0.5% methylcellulose. Repeated-measures or one-way ANOVA followed by a post hoc Tukey honestly significant difference test were used for statistical analysis. *P < 0.05 vs. Veh; #P < 0.05 vs. Ipra. Values are expressed as means ± SE; n = 5–12/group.