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Effect of ipragliflozin (Ipra), furosemide (Furo), or vehicle (Veh) on urine vasopressin excretion (A), solute-free water reabsorption (B), change in serum Na+ (C), and change in serum Cl− (D) on day 2 in nondiabetic Sprague-Dawley rats. Drug doses are as in Fig. 1. One-way ANOVA followed by a post hoc Tukey honestly significant difference test were used for statistical analysis. Values are expressed as means ± SE; n = 7–15/group. bw, body weight.
