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Effect of ipragliflozin (Ipra), furosemide (Furo), or vehicle (Veh) on change in plasma volume (A), plasma renin activity (B), and systolic blood pressure (C) on day 2 in nondiabetic Sprague–Dawley rats. Drug doses are as in Fig. 1. One-way ANOVA followed by a post hoc Tukey honestly significant difference test were used for statistical analysis. Values are expressed as means ± SE; n = 6–11/group.
