Table 3.

The area under the receiver operating curves (AUROC) of plasma NGAL, plasma PENK, plasma NT-proBNP, uNT-proBNP/uCr ratio, and plasma PENK + uNT-proBNP/uCr for predicting CRS-1 in ADHF patients.

Variables	Cutoff value	Youden index	AUROC (95% CI)	P Value	Z-statistic	Sensitivity	Specificity
Plasma NGAL	56.5	0.567	0.808 (0.726–0.874)	<0.001	5.900	0.6452	0.9222
Plasma PENK	57.0	0.725	0.899 (0.831–0.946)	<0.001	11.900	0.9032	0.8222
uNT-proBNP/uCr	119.0	0.793	0.934 (0.874–0.971)	<0.001	15.618	0.8710	0.9222
Plasma PENK + uNT-proBNP/uCr	–	0.822	0.976 (0.930–0.995)	<0.001	42.921	0.9677	0.8222

CRS-1: cardiorenal syndrome type 1; ADHF: acute decompensated heart failure; AUROC: area under the receiver operating curves; NT-proBNP: Amino-terminal pro-B-type natriuretic peptide; uNT-proBNP: urine NT-proBNP; uCr: urine creatinine; NGAL: neutrophil gelatinase-associated lipocalin; PENK: preproenkephalin.