Table 3.
Final linear regression model predicting BMI at 17 years old. Linear regression model for the outcome of BMI at 17-years was formed by backward selection with pre-pregnancy BMI, maternal smoking at 18-weeks gestation and GWG, all pyrosequenced CpGs, cell counts and potential me-QTLs (rs6565624_G, rs3830068_G, rs12452184_A). The model (r2 = 0.243 (SE = 0.15), includes independent effects of rs6565624_G, MSI2 CpG1, RAPH1, maternal smoking at 18-weeks, pre-pregnancy BMI, CD8+, CD4 + T cells, and granulocytes.
Parameter | Beta | SE | Sig. |
---|---|---|---|
rs6565624_G | 0.043 | 0.012 | 3.8 x 10−4 |
RAPH1 (Z score) | 0.088 | 0.020 | 8.4 x 10 −6 |
MSI2 CpG1 (Z score) | 0.021 | 0.009 | 0.022 |
Maternal smoking at 18 weeks pregnancy | 0.052 | 0.018 | 0.004 |
Prepregnancy BMI (kg/m2) | 0.015 | 0.002 | 1.1 x10−17 |
CD8 + T Cells | 0.417 | 0.220 | 0.058 |
CD4 + T Cells | 1.069 | 0.226 | 2.8 x 10 −6 |
Granulocytes | 0.325 | 0.143 | 0.024 |
Model summary R2 = 0.24