Fig. 1.

TCR Repertoire Diversity and Clonality in MIS-C. A-B) Shannon Entropy, a measure of repertoire diversity, estimated at fixed sample coverage. C—D) Median frequency (percent) among the top 100 most frequent clones with T cell clone defined as amino acid sequence in CDR3β of the TCR. Summary data on bar graphs is mean ± standard error. Statistical testing for A-D: Kruskal-Wallis test with Dunn's multiple comparisons test. P value * ≤ 0.05, *** ≤ 0.001. CDR3, complementarity determining region 3; TCR, T cell receptor; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; MIS-C, multisystem inflammatory syndrome in children; peds, pediatric; ctrls, controls; KD, Kawasaki disease; sJIA, systemic juvenile idiopathic arthritis; MAS, macrophage activation syndrome.