Table 2.
Effect of polyherbal recipe extracts on castor oil-induced diarrhea.
| Groups | Onset of diarrhea (min) | No. of diarrheal feces | Inhibition of diarrhea % | Total no. of feces | Inhibition of defecation % | Total weight of feces | Rats with diarrhea | % rats protected |
|---|---|---|---|---|---|---|---|---|
| Control (normal saline + co) | 69.66 ± 7.23 | 8.66 ± 0.57 | — | 8.66 ± 0.57 | — | 1.63 ± 0.15 | 3 | 0 |
| Loperamide 5 mg/kg + co | 211 ± 4.58∗∗∗ | 0.66 ± 0.57 | 92.37 | 4.99 ± 2.07 | 42.37 | 0.70 ± 0.1∗∗ | 1 | 66.66 |
| Recipe 100 mg/kg + co | 196.66 ± 75.05 | 0.66 ± 0.57 | 92.37 | 1.99 ± 0.63 | 77.02 | 1.16 ± 0.85∗ | 1 | 66.66 |
| Recipe 200 mg/kg + co | 240 ± 0∗∗∗ | 0 | 100 | 0.66 ± 0.51 | 92.37 | 0.26 ± 0.25∗ | 0 | 100 |
| Recipe 400 mg/kg + co | 240 ± 0∗∗∗ | 0 | 100 | 0 | 100 | 0∗∗ | 0 | 100 |
Values taken as mean ± SEM (n = 3), one-way ANOVA. ∗∗ = P < 0.01, ∗∗∗ = P < 0.0001, and ns = nonsignificant versus control.