. 2021 May 27;44(3):671–678. doi: 10.1093/pubmed/fdab157
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Fig. 1 .
What is argued for through use of the ‘upstream–downstream’ metaphor?