Table 2.
Case Reports of DNTM Seropositive for Anti-IFN-γ Antibodies from Japan.
| Case | Age (years)/ Sex |
Underlying condition | Strain | Symptom/Findings | Treatment | Outcome | Reference |
|---|---|---|---|---|---|---|---|
| 1 | 53/M | Unknown | M. kansasii | Dyspnea, anemia, mediastinal lymphadenopathy | RFP/EB/INH | Died | (22) |
| 2 | 66/M | Hepatitis C | M. avium complex | Fever, back pain, joint pain, myalgia, lung lesion, mediastinal lymphadenopathy | RFP/EB/CAM/ LVFX+drainage |
Improved | (23) |
| 3 | 74/W | None | M. fortuitum | Fever, cough, lung lesion, cervical lymphadenopathy | IPM/CS+AMK → LVFX/CAM | Improved | (24) |
| 4 | 65/M | Unknown |
M. gordonae/
M. manteni |
Fever, weight loss, cervical lymphadenopathy, lung lesion, bone lesion | RFP/EB/CAM | Improved | (25) |
| 5 | 67/W | Diabetes mellitus | M. avium complex | Fever, weight loss, lumbago, hepatosplenomegaly, edema, osteolytic lesion | RFP/EB/CAM/ STFX+RTX |
Improved | (26) |
| 6 | 79/W | None | M. phlei | Chest pain, erythema, multiple lymphadenopathy, osteolytic lesion, hepatosplenomegaly | RFP/EB/CAM/ LVFX |
Improved | (27) |
| 7 | 74/W | Unknown | M. avium | Lymphadenopathy, abscess | RFP/EB/CAM | Improved | (28) |
| 8 | 33/M | None | M. kansasii | Fever, cough, multiple lymphadenopathy, pericardial effusion, pleural effusion | RFP/EB/INH/PZA | Improved | (29) |
| 9 | 68/M | None | M. avium | Fever, weight loss, lung lesion, osteolytic lesion, hepatosplenomegaly, ascites, intraperitoneal lymphadenopathy | RFP/EB/CAM/SM → add STFX | Improved | (30) |
| 10 | 65/M | None | M. avium | Erythema, weight loss, numbness, multiple lymphadenopathy, osteolytic lesion, abscess | RFP/EB/CAM → CAM/RBT/EB/SM +IFN-γ s.c. | Improved | (31) |
| 11 | 78/M | Cervical spondylosis, hypertension | M. abium | Fever, weight loss, multiple lymphadenopathy, lung lesion, osteolytic lesion, pleural effusion | RFP/EB/CAM/SM | Improved | (32) |
| 12 | 49/W | None | M. abscessus | Fever, multiple lymphadenopathy, bone lesion | MEPM/AMK/CAM | Improved | (33) |
| 13 | 72/M | Hypertension hyperuricemia, ossification of cervical posterior longitudinal ligament | M. abium | Fever, abdominal pain, renal swelling, osteolytic lesion, lung lesion | RFP/CAM+ Glucocorticoid | Died | (34) |
| 14 | 64/M | None | M. kansasii | Fever, polyarthralgia, multiple cellulitis, pleural effusion, ascites, hepatosplenomegaly, multiple lymphadenopathy, osteolytic lesion | RFP/EB/CAM → RFP/EB/CAM/INH +Glucocorticoid/IVIg | Improved | - |
Case 14 is our case.
RFP: rifampicin, EB: ethambutol, INH: isoniazid, CAM: clarithromycin, LVFX: levofloxacin, IPM/CS: imipenem/cilastatin, AMK: amikacin, STFX: sitafloxacin, RTX: rituximab, PZA: pyrazinamide, SM: streptomycin, RBT: rifabutin, IFN-γ s.c.: interferon-gamma subcutaneous injection, MEPM: meropenem, M: man, W: woman