Fig. 1. Infiltrating lymphocytes, scored by tissue-microarray analysis, are strongly associated with CRC patient prognosis.
Intraepithelial (ie) CD8- and stromal (s) CD3-scores were dichotomized at the median within the pooled cohorts, resulting in four groups; ieCD8HighsCD3High, ieCD8HighsCD3Low, ieCD8LowsCD3High and ieCD8LowsCD3Low. Representative images of tissue-cores for each of these categories are displayed (red; CD3, green; CD8, purple; epithelial (tumor) markers, white; DAPI). Scale-bar equals 200μm.