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. 2022 Jul 14;45(4):677–687. doi: 10.1007/s13402-022-00691-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Flow chart of genomic and transcriptomic analyses and overview of the Renji-mccRCC cohort with first-line VEGF-TKI therapy and its somatic mutation landscape. (A) All 56 patients underwent targeted genome sequencing, and 40 were analyzed by whole transcriptome sequencing. The overall study design and main results are shown in the flow chart. (B) The top 40 genes of the somatic mutation oncoplot are shown. VHL mutations were found in 35 (66%) of the patients, followed by PBRM1 mutations in 20 (38%) patients and SETD2 mutations in 10 (19%) patients