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. 2022 Aug 29;8:376. doi: 10.1038/s41420-022-01169-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Three genes that were co-upregulated were identified by RNA-seq and TMT in Bel-7402 and Bel-7404 cells. B–D The candidates were further screened by adding CA and ferroptosis inducers. qPCR experiment was used to detect the mRNA of these three candidate genes after adding drugs. E HERPUD1, HMGCS1, and GDF15 expression were measured by immunoblotting in liver cancer cell lines (Bel-7402 and Bel-7404), as indicated. The IB data are representative images from three biological replicates. F Densitometric analysis of HERPUD1 protein expression in Bel-7402 and Bel-7404 cells normalized to housekeeping protein GAPDH. Data were analyzed using Student’s t test and expressed as mean ± SD. ***P < 0.001; ****P < 0.0001.