Table 1.

Effects of CKD-581 on HDAC enzymes. HDAC enzyme activity was determined by fluorescence based-enzymatic assays

HDAC enzyme assay IC50 (nM)
Class I	HDAC1	0.50 ± 0.11
	HDAC2	2.22 ± 0.39
	HDAC3	0.61 ± 0.09
	HDAC8	49.82 ± 18.24
Class IIa	HDAC4	1502 ± 109
	HDAC9	0.95 ± 0.69
	HDAC11	26.91 ± 19.12
Class IIb	HDAC6	2.62 ± 0.32
	HDAC10	1.14 ± 0.76