Fig. 2.

The role of mitochondrial dysfunction in the development of diabetic cardiomyopathy. In diabetic heart, mitochondria are suffered from imbalanced dynamics, damaged biogenesis, and impaired mitophagy. Conversely, mitochondrial dysfunction may be explained by reduced ATP production and ROS damage, leading to cardiac structural, electrical, and functional disorder. ADP, adenosine-diphosphate; ATP, adenosine-triphosphate; TCA, tricarboxylic acid cycle; FAO, Fatty Acid Oxidation; OXPHOS, oxidative phosphorylation; ROS, reactive oxygen species; mtDNA, mitochondrial DNA.