Table 1.
Stimulators and inhibitors of mitochondrial biogenesis in animal DCM models
| Types | DCM models | Mechanisms | References | |
|---|---|---|---|---|
| Stimulators | ||||
| Melatonin | T1DM | STZ injection mice | SIRT3/Mst1 | Yu et al., 2021 |
| T2DM | High-fat diet and STZ injection rats | SIRT6, AMPK-PGC-1α-AKT | Zhang et al., 2017 | |
| Resveratrol | T2DM | High-fat diet and STZ injection rats | SIRT1-PGC-1α deacetylation | Fang et al., 2018 |
| SIRT1 deletion mice | SIRT1-PGC-1α deacetylation | Ma et al., 2017 | ||
| Salidroside | T2DM | High-fat and STZ-injection mice | SIRT3, AMPK/AKT/PGC-1α-TFAM | Li et al., 2021b |
| Pterostillbene | T1DM | High-glucose diet rats | AMPK/NRF2/HO-1/PGC-1α | Kosuru et al., 2018 |
| miR-144 | T1DM | STZ-injection mice | Rac-1/AMPK/PGC-1α | Tao et al., 2020 |
| BH4 | T2DM | OLETF rats | CaMKK2-AMPK/CAMP/CREB/PGC-1α | Kim et al., 2020 |
| Exercise | ||||
| Resistance | T2DM | OLETF rats | UCP2/UCP3 | Ko et al., 2018 |
| Moderate | T2DM | Db/db mice | CXC3 | Veeranki et al., 2016 |
| Ensurance | T2DM | Db/db mice | PGC-1α-AKT | Wang et al., 2015 |
| Inhibitors | ||||
| ADMA | T2DM | High-fat and STZ injection rats | PGC-1α phosphorylation and acetylation | Xiong et al., 2020 |
| T1DM | STZ injection rats | NO/PGC-1α | Xiong et al., 2021 | |
T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; STZ, streptozotocin; OLETF, Otsuka long-evans Tokushima fatty; BH4, tetrahydrobiopterin; ADMA, asymmetric dimethylarginine.