Table 2.
Glucose-lowering drugs and mitochondrial biogenesis
| Drugs | Types | Diabetic models | Mechanisms | References |
|---|---|---|---|---|
| Empagliflozin | T2DM | High-fat and STZ injection rats | PGC-1α-NRF1-TFAM | Habibi et al., 2017 |
| Alogliptin | T1DM | Alloxan-induced rabbits | PGC-1α-NRF1-TFAM | Zhang et al., 2018 |
| Metformin | T1DM | High glucose-induced cardiomyocytes | PGC-1α-NRF1-TFAM | Packer, 2020 |
| Pioglitazone | T1DM | Alloxan-induced mice | PGC-1α | Zhang et al., 2021 |
T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; STZ, streptozotocin.